ChemicalBook CAS DataBase List TERT-BUTYL 4-[2-(HYDROXYMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

TERT-BUTYL 4-[2-(HYDROXYMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE synthesis

7synthesis methods

Product Name:TERT-BUTYL 4-[2-(HYDROXYMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE
CAS Number:179250-28-3
Molecular formula:C16H24N2O3
Molecular Weight:292.37

174855-57-3
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$11.00/250mg

TERT-BUTYL 4-[2-(HYDROXYMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

179250-28-3
25 suppliers
$175.00/500mg

Yield:179250-28-3 89%

Reaction Conditions:

with sodium tetrahydroborate in methanol at 0 - 20; for 2 h;

Steps:

1.2 Step 2) Synthesis of 4- (2- (hydroxymethyl) phenyl) piperazine-1-carboxylic acid tert-butyl ester

Dissolve tert-butyl 4- (2-formylphenyl) piperazine-1-carboxylate (4.0 g, 13.8 mmol) in methanol (69 mL),Sodium borohydride (0.87 g, 20.7 mmol) was added at 0 ° C. After the addition was completed, the reaction was carried out at room temperature for 2 hours. Stop reactionIt was quenched with water and extracted with dichloromethane. The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure.The obtained crude product was further purified by a silica gel chromatography column (petroleum ether: ethyl acetate (V: V) = 5: 1) to obtain the title compound.(Light yellow solid, 3.6 g, 89%).

References:

CN108299338,2018,A Location in patent:Paragraph 0142; 0148; 0149; 0150; 0151