![](/StructureFile/ChemBookStructure7/GIF/CB4778396.gif)
3-AMINO-4-METHYL-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER synthesis
- Product Name:3-AMINO-4-METHYL-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER
- CAS Number:160133-79-9
- Molecular formula:C13H13NO2S
- Molecular Weight:247.31
![Bromobenzene](/CAS/GIF/108-86-1.gif)
108-86-1
493 suppliers
$10.00/5g
![Methyl 3-amino-4-methylthiophene-2-carboxylate](/CAS/GIF/85006-31-1.gif)
85006-31-1
359 suppliers
$5.00/5g
![3-AMINO-4-METHYL-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER](/StructureFile/ChemBookStructure7/GIF/CB4778396.gif)
160133-79-9
11 suppliers
$127.00/1g
Yield: 66%
Reaction Conditions:
with PdCl(C3H5)(dppb);potassium acetate in N,N-dimethyl acetamide at 120; for 20 h;Inert atmosphere;
Steps:
4.2. General procedure for the synthesis of products 1a and 2-36
General procedure: As a typical experiment, the reaction of 4-(trifluoromethyl)bromobenzene (0.225 g, 1 mmol), methyl 3-amino-4-methylthiophene-2-carboxylate (0.342 g, 2 mmol) and KOAc (0.196 g, 2 mmol) at 120 °C during 20 h in DMAc (3 mL) in the presence of PdCl(C3H5)(dppb) (12.2 mg, 0.02 mmol) under argon affords methyl 3-amino-4-methyl-5-(4-trifluoromethylphenyl)-thiophene-2-carboxylate 1a after extraction with dichloromethane, evaporation and filtration on silica gel (pentane/ether) in 82% (0.258 g) yield.
References:
Derridj, Fazia;Si Larbi, Karima;Roger, Julien;Djebbar, Safia;Doucet, Henri [Tetrahedron,2012,vol. 68,# 36,p. 7463 - 7471] Location in patent:experimental part
![Phenyl trifluoromethanesulfonate](/CAS/GIF/17763-67-6.gif)
17763-67-6
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$13.00/1g
![Methyl 3-amino-4-methylthiophene-2-carboxylate](/CAS/GIF/85006-31-1.gif)
85006-31-1
359 suppliers
$5.00/5g
![3-AMINO-4-METHYL-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER](/StructureFile/ChemBookStructure7/GIF/CB4778396.gif)
160133-79-9
11 suppliers
$127.00/1g
![Methyl thioglycolate](/CAS/GIF/2365-48-2.gif)
2365-48-2
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$15.00/25g
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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![3-AMINO-4-METHYL-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER](/StructureFile/ChemBookStructure7/GIF/CB4778396.gif)
160133-79-9
11 suppliers
$127.00/1g
![2-Propenal, 3-chloro-2-methyl-3-phenyl-](/CAS/20210305/GIF/35811-93-9.gif)
35811-93-9
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![3-AMINO-4-METHYL-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER](/StructureFile/ChemBookStructure7/GIF/CB4778396.gif)
160133-79-9
11 suppliers
$127.00/1g