(S)-7-chloro-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one synthesis
- Product Name:(S)-7-chloro-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one
- CAS Number:1620579-40-9
- Molecular formula:C8H10ClN3O
- Molecular Weight:199.64
![(S)-7-chloro-2-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one](/CAS/20180703/GIF/1620579-34-1.gif)
Yield:1620579-40-9 1.2 g
Reaction Conditions:
with potassium carbonate in acetone at 20; for 18 h;
Steps:
Intermediate 7: (S)-7-chloro-l,2-dimethyl-2,3-dihydroimidazo[l,2-c]pyrimidin-5(lH)-one
Intermediate 7: (S)-7-chloro-l,2-dimethyl-2,3-dihydroimidazo[l,2-c]pyrimidin-5(lH)-one
To a solution of Sj-7-chloro-2-methyl-2,3-dihydroimidazo[l,2-c]pyrimidin-5(l/-/)-one (2 g, 10.78 mmol) in acetone (20 mL) was added K2C03 (2.98 g, 21.55 mmol) and Mel (0.674 mL, 10.78 mmol) and the reaction mixture stirred at RT for 18 h. The reaction mixture was evaporated under reduced pressure to give crude material (4.2 g) which was purified by column chromatography using 5% MeOH/DCM as eluent. The product containing fractions were evaporated to give the title compound (1.2 g) as an off-white solid. (0220) *H NM (400 MHz, DMSO-d6) δ: 5.88 (1H, s), 4.16-4.09 (2H, m), 3.55-3.51 (1H, m), 2.88 (3H, s), 1.29 (3H, d).
References:
WO2016/12916,2016,A1 Location in patent:Page/Page column 26; 27
1620579-30-7
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1620579-40-9
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