Pyrrolo[2,3-b]pyridin-1-yl-acetic acid Methyl ester synthesis
- Product Name:Pyrrolo[2,3-b]pyridin-1-yl-acetic acid Methyl ester
- CAS Number:172647-94-8
- Molecular formula:C10H10N2O2
- Molecular Weight:190.2
271-63-6
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96-32-2
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33140-80-6
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172647-94-8
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Yield:172647-94-8 55% by weight
Reaction Conditions:
in N-methyl-acetamide;mineral oil;
Steps:
17 Methyl 7-azaindol-1-acetate
PREPARATION 17 Methyl 7-azaindol-1-acetate A procedure similar to that described in Preparation 12 was repeated, except that 1.90 g of sodium hydride (as a 55% by weight dispersion in mineral oil), 4.95 g of 7-azaindol, 100 ml of dimethylformamide and 4.2 ml of methyl bromoacetate were used, to give 7.70 g of the title compound having Rf=0.33 (on silica gel thin layer chromatography using a 2:1 by volume mixture of hexane and ethyl acetate as the developing solvent).
References:
US5624935,1997,A