Ethyl 2-amino-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylate synthesis
- Product Name:Ethyl 2-amino-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylate
- CAS Number:174072-89-0
- Molecular formula:C14H14N2O4S
- Molecular Weight:306.34
5332-96-7
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Yield:174072-89-0 85%
Reaction Conditions:
with sulfur;N-butylamine in ethanol at 40 - 50; for 2 h;Large scale;
Steps:
2 Preparation of 2-amino-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylic acid ethyl ester
Dissolve 1 kg of 1-(4-nitrophenyl)propan-2-one in 4L of ethanol, add 685 g of ethyl cyanoacetate and 195 g of sulfur, and stir.The temperature was raised to 40°C, 200 g of n-butylamine was added, and the temperature was raised to 50°C and stirred for 2 hours.Cool down to about 10°C and stir for 1 hour.After filtration, the filter cake was rinsed with 2L ethanol to obtain 1.37 kg of product, with a purity of 99% and a yield of 85.0%.
References:
Jiangsu Haiyuekang Pharmaceutical Technology Co., Ltd.;Shen Haojian;Zhang Jianming;Chen Geng;Pei Xinyu;Jiang Chunyang;Xie Jun;Li Hui CN111440188, 2020, A Location in patent:Paragraph 0058-0061
5332-96-7
131 suppliers
$38.79/1g
174072-89-0
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105-56-6
433 suppliers
$10.00/5ml
174072-89-0
122 suppliers
inquiry
586-78-7
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$14.00/5g
174072-89-0
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104-03-0
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$5.00/10g
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