Phosphonic acid, P-[(4-bromophenyl)difluoromethyl]-, diethyl ester synthesis
- Product Name:Phosphonic acid, P-[(4-bromophenyl)difluoromethyl]-, diethyl ester
- CAS Number:177284-56-9
- Molecular formula:C11H14BrF2O3P
- Molecular Weight:343.1
Yield:177284-56-9 97%
Reaction Conditions:
Stage #1: diethyl (bromodifluoromethyl)phosphonatewith zinc in N,N-dimethyl acetamide at 55; for 3.5 h;Inert atmosphere;Sonication;
Stage #2: with copper(I) bromide in N,N-dimethyl acetamide at 23; for 0.5 h;Inert atmosphere;
Stage #3: 1,4-bromoiodobenzene in N,N-dimethyl acetamide at 23; for 20 h;Inert atmosphere;
References:
Witten, Michael R.;Wissler, Lisa;Snow, Melanie;Geschwindner, Stefan;Read, Jon A.;Brandon, Nicholas J.;Nairn, Angus C.;Lombroso, Paul J.;K?ck, Helena;Ellman, Jonathan A. [Journal of Medicinal Chemistry,2017,vol. 60,# 22,p. 9299 - 9319]
589-87-7
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177284-56-9
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5467-74-3
450 suppliers
$8.00/1g
80077-72-1
17 suppliers
$65.00/100mg
177284-56-9
10 suppliers
inquiry