![](/CAS/GIF/17455-13-9.gif)
18-Crown-6 synthesis
- Product Name:18-Crown-6
- CAS Number:17455-13-9
- Molecular formula:C12H24O6
- Molecular Weight:264.32
![Triethylene glycol](/CAS/GIF/112-27-6.gif)
112-27-6
738 suppliers
$6.00/100g
![18-Crown-6](/CAS/GIF/17455-13-9.gif)
17455-13-9
615 suppliers
$5.00/10g
Yield:17455-13-9 65.2%
Reaction Conditions:
with 4-methylbenzene-1-sulfonyl chloride;potassium hydroxide in tetrahydrofuran at 55 - 60; for 3 h;
Steps:
1-3 Example 2
A preparation method of 18-crown-6, the production steps are as follows:(1) Weigh 15g of triethylene glycol and 12g of potassium hydroxide into a 500mL reaction bottle, then add 300mL of tetrahydrofuran to the reaction bottle, and start stirring;(2) Add 19g of p-toluenesulfonyl chloride dropwise to the reaction bottle, control the reaction temperature at 55-60 , and react for 3h;(3) Add 7.7g of diethyl sulfate to the solution after the reaction to separate potassium p-toluenesulfonate, control the reaction temperature at 80 ° C, and react for 3h to produce diethyl p-toluenesulfonate and potassium sulfate;(4) The final solution obtained after the reaction is filtered, concentrated, and vacuum distilled, and the distillate contains 18-crown-6, diethyl p-toluenesulfonate, triethylene glycol, etc .;(5) After washing the distillate with 20 mL of distilled water and leaving it to separate into layers, the upper layer solution is diethyl p-toluenesulfonate, the lower layer solution is 18-crown-6, triethylene glycol, etc. The lower layer solution is centrifugally separated Precipitation, the precipitate is dried to obtain 18-crown-6.The mass of 18-crown-6 finally prepared was 17.2 g, and the yield was 65.2%.
References:
CN110759886,2020,A Location in patent:Paragraph 0022-0045
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112-26-5
216 suppliers
$6.00/10g
![Triethylene glycol](/CAS/GIF/112-27-6.gif)
112-27-6
738 suppliers
$6.00/100g
![18-Crown-6](/CAS/GIF/17455-13-9.gif)
17455-13-9
615 suppliers
$5.00/10g
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347 suppliers
$7.00/25g
![DIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE)](/CAS/GIF/7460-82-4.gif)
7460-82-4
220 suppliers
$6.00/1g
![18-Crown-6](/CAS/GIF/17455-13-9.gif)
17455-13-9
615 suppliers
$5.00/10g
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19249-03-7
221 suppliers
$9.00/1g
![Triethylene glycol](/CAS/GIF/112-27-6.gif)
112-27-6
738 suppliers
$6.00/100g
![18-Crown-6](/CAS/GIF/17455-13-9.gif)
17455-13-9
615 suppliers
$5.00/10g
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4792-15-8
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$6.00/1g
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6315-52-2
185 suppliers
$5.00/1g
![18-Crown-6](/CAS/GIF/17455-13-9.gif)
17455-13-9
615 suppliers
$5.00/10g