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ChemicalBook CAS DataBase List 1-Piperidinecarboxylic acid, 4-(Methylsulfonyl)-, 1,1-diMethylethyl ester

1-Piperidinecarboxylic acid, 4-(Methylsulfonyl)-, 1,1-diMethylethyl ester synthesis

4synthesis methods
208245-69-6 Synthesis
tert-butyl 4-(methylthio)piperidine-1-carboxylate

208245-69-6
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1-Piperidinecarboxylic acid, 4-(Methylsulfonyl)-, 1,1-diMethylethyl ester

189205-49-0
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Yield:189205-49-0 92%

Reaction Conditions:

with 3-chloro-benzenecarboperoxoic acid in dichloromethane at 0 - 20;

Steps:

14.1

To a solution of tert-butyl 4-(methylthio)piperidine- 1 -carboxylate (280 mg, 1.2 mmol) (reagent preparation 12, step 2) in dichloromethane (8 mL) was added m-chloroperbenzoic acid (835 mg, 4.8 mmol) at 0 0C. The solution was warmed to room temperature and stirred for 15 h. The reaction mixture was partitioned between IN sodium hydroxide and ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate, filtered and concentrated to give tert-butyl 4-(methylsulfonyl)piperidine-l- carboxylate (290 mg, 92% yield). MS (EI) for CnH2iNO4S: 206 (M-tBu+).

References:

WO2010/138487,2010,A1 Location in patent:Page/Page column 123

109384-19-2 Synthesis
N-BOC-4-Hydroxypiperidine

109384-19-2
470 suppliers
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1-Piperidinecarboxylic acid, 4-(Methylsulfonyl)-, 1,1-diMethylethyl ester

189205-49-0
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141699-59-4 Synthesis
1-Boc-4-methanesulfonyloxypiperidine

141699-59-4
233 suppliers
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1-Piperidinecarboxylic acid, 4-(Methylsulfonyl)-, 1,1-diMethylethyl ester

189205-49-0
32 suppliers
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