ChemicalBook CAS DataBase List (1R,5S)-6,6-diMethyl-3-azabicyclo[3.1.0]hexane-2,4-dione

(1R,5S)-6,6-diMethyl-3-azabicyclo[3.1.0]hexane-2,4-dione synthesis

6synthesis methods

Product Name:(1R,5S)-6,6-diMethyl-3-azabicyclo[3.1.0]hexane-2,4-dione
CAS Number:194421-56-2
Molecular formula:C7H9NO2
Molecular Weight:139.15

67911-21-1 Synthesis

67911-21-1
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$6.00/1g

(1R,5S)-6,6-diMethyl-3-azabicyclo[3.1.0]hexane-2,4-dione

194421-56-2
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$10.00/100mg

Yield:194421-56-2 92%

Reaction Conditions:

with ammonia at 145; under 90009 Torr; for 2 h;Autoclave;

Steps:

1.2; 2.2; 1.2

Step 2, adding 66g caronic anhydride to the autoclave, inject ammonia into the autoclave simultaneously (the mol ratio of caron anhydride and ammonia is 1:3), seal the autoclave; heat the autoclave And stir to make it reach the supercritical ammonia condition at a temperature of 145°C and a pressure of 12MPa, heat preservation and pressure retention for 120min, cool the autoclave to 70°C, release the pressure, add 60°C hot water, cool down and stir for crystallization for 2h , filtered with suction, washed with ice water, and dried at 45°C to obtain compound A (yield 92%);

References:

CN114702431,2022,A Location in patent:Paragraph 0023; 0026-0028; 0032; 0035-0037; 0040; 0043

541-59-3 Synthesis