ChemicalBook CAS DataBase List 6,6-DiMethyl-3-azabicyclo[3.1.0]hexane Boceprevir Key interMediate

6,6-DiMethyl-3-azabicyclo[3.1.0]hexane Boceprevir Key interMediate synthesis

6synthesis methods

Product Name:6,6-DiMethyl-3-azabicyclo[3.1.0]hexane Boceprevir Key interMediate
CAS Number:943516-54-9
Molecular formula:C7H13N
Molecular Weight:111.18

6,6-Dimethyl-3-azabicyclo[3.1.0]hexane is synthesised with 3-benzyl-6, 6-dimethyl-3-azabicyclo [3.1.0] hexane and platinum and methanol in autoclave.

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6,6-DiMethyl-3-azabicyclo[3.1.0]hexane Boceprevir Key interMediate

943516-54-9
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Yield:943516-54-9 97%

Reaction Conditions:

with palladium-carbon in methanol at 0 - 30; for 6 h;

Steps:

9 Example 9: Synthesis of 6,6-dimethyl-3-azabicyclo[3.1.0]hexane

To a solution of 3-benzyl-6,6-dimethyl-3-azabicyclo[3.1.0]hexane (25.00 g) in methanol (250 mL) was added palladium on carbon (5%, 2.5 g) at room temperature , the reaction was stirred at room temperature for 6 h, the palladium carbon was removed by filtration, and the methanol was removed by concentration to obtain 6,6-dimethyl-3-azabicyclo[3.1.0]hexane (13.39 g, 97%).

References:

CN114605311,2022,A Location in patent:Paragraph 0045; 0055