ChemicalBook CAS DataBase List 4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-1-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID

4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-1-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID synthesis

11synthesis methods

Product Name:4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-1-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID
CAS Number:195387-29-2
Molecular formula:C21H18N2O4
Molecular Weight:362.38

1H-Pyrrole-2-carboxylic acid, 4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1-methyl-, 1,1-dimethylethyl ester

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4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-1-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID

195387-29-2
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Yield: 96.1%

Reaction Conditions:

with water in dichloromethane at -5 - 5;Inert atmosphere;

Steps:

11 Synthesis of Compound g1
Add f1 (165.0 g, 393 mmol) to DCM (1.8 L)under the protection of nitrogen and warm to -5-0 °C. 0-5 °C reaction 0.5~lh. Add water (1.5 L), stir for 2 to 3 h, filter and dry to obtain 137.2 g of white solid g1.Yield:96.1%.

References:

Shanghai Maosheng Kanghui Technology Co., Ltd.;Ying Yongcheng;Wang Tiantian;Yi Tao;Jiang Xuefeng;Yu Fei CN109970617, 2019, A Location in patent:Paragraph 0072; 0135-0138

82911-69-1 Synthesis