![](/StructureFile/ChemBookStructure22/GIF/CB7507492.gif)
METHYL (2S,4R)-1-(TERT-BUTOXYCARBONYL)-4-METHYLPYROGLUTAMATE synthesis
- Product Name:METHYL (2S,4R)-1-(TERT-BUTOXYCARBONYL)-4-METHYLPYROGLUTAMATE
- CAS Number:196394-49-7
- Molecular formula:C12H19NO5
- Molecular Weight:257.28
![1-(tert-butyl) 2-methyl (S,E)-4-((dimethylamino)methylene)-5-oxopyrrolidine-1,2-dicarboxylate](/CAS/20210305/GIF/196394-47-5.gif)
196394-47-5
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![METHYL (2S,4R)-1-(TERT-BUTOXYCARBONYL)-4-METHYLPYROGLUTAMATE](/StructureFile/ChemBookStructure22/GIF/CB7507492.gif)
196394-49-7
26 suppliers
$120.00/10mg
![METHYL (2S,4S)-1-(TERT-BUTOXYCARBONYL)-4-METHYLPYROGLUTAMATE](/StructureFile/ChemBookStructure22/GIF/CB0507493.gif)
196394-48-6
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Yield:196394-48-6 80% ,196394-49-7 1.3%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in ethyl acetate;isopropanol at 20; under 10343.2 Torr; for 72 h;Autoclave;stereoselective reaction;
References:
Caporale, Andrea;O′ Loughlin, Jennie;Ortin, Yannick;Rubini, Marina [Organic and Biomolecular Chemistry,2022,vol. 20,# 32,p. 6324 - 6328] Location in patent:supporting information
![Boc-L-Pyroglutamic acid methyl ester](/CAS/GIF/108963-96-8.gif)
108963-96-8
278 suppliers
$5.00/1g
![Iodomethane](/CAS/GIF/74-88-4.gif)
74-88-4
341 suppliers
$15.00/10g
![METHYL (2S,4R)-1-(TERT-BUTOXYCARBONYL)-4-METHYLPYROGLUTAMATE](/StructureFile/ChemBookStructure22/GIF/CB7507492.gif)
196394-49-7
26 suppliers
$120.00/10mg
![1,2-Pyrrolidinedicarboxylic acid, 4-[(dimethylamino)methylene]-5-oxo-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,4E)-](/CAS/20210305/GIF/219844-08-3.gif)
219844-08-3
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![METHYL (2S,4R)-1-(TERT-BUTOXYCARBONYL)-4-METHYLPYROGLUTAMATE](/StructureFile/ChemBookStructure22/GIF/CB7507492.gif)
196394-49-7
26 suppliers
$120.00/10mg
![METHYL (2S,4S)-1-(TERT-BUTOXYCARBONYL)-4-METHYLPYROGLUTAMATE](/StructureFile/ChemBookStructure22/GIF/CB0507493.gif)
196394-48-6
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![L-Pyroglutamic acid](/CAS/GIF/98-79-3.gif)
98-79-3
599 suppliers
$5.00/25g
![METHYL (2S,4R)-1-(TERT-BUTOXYCARBONYL)-4-METHYLPYROGLUTAMATE](/StructureFile/ChemBookStructure22/GIF/CB7507492.gif)
196394-49-7
26 suppliers
$120.00/10mg
![Boc-L-Pyroglutamic acid methyl ester](/CAS/GIF/108963-96-8.gif)
108963-96-8
278 suppliers
$5.00/1g
![Iodomethane](/CAS/GIF/74-88-4.gif)
74-88-4
341 suppliers
$15.00/10g
![METHYL (2S,4R)-1-(TERT-BUTOXYCARBONYL)-4-METHYLPYROGLUTAMATE](/StructureFile/ChemBookStructure22/GIF/CB7507492.gif)
196394-49-7
26 suppliers
$120.00/10mg
![METHYL (2S,4S)-1-(TERT-BUTOXYCARBONYL)-4-METHYLPYROGLUTAMATE](/StructureFile/ChemBookStructure22/GIF/CB0507493.gif)
196394-48-6
13 suppliers
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