ChemicalBook CAS DataBase List 4-(4-Halophenyl)-1,2,3,6-terahydropyridinehydrochloride

4-(4-Halophenyl)-1,2,3,6-terahydropyridinehydrochloride synthesis

12synthesis methods

Product Name:4-(4-Halophenyl)-1,2,3,6-terahydropyridinehydrochloride
CAS Number:1978-59-2
Molecular formula:C11H12FN
Molecular Weight:177.22

138647-52-6 Synthesis

tert-butyl 4-(4-fluorophenyl)-5,6-dihydropyridine-1(2H)-carboxylate

138647-52-6
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4-(4-Halophenyl)-1,2,3,6-terahydropyridinehydrochloride

1978-59-2
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Yield:1978-59-2 95%

Reaction Conditions:

with hydrogenchloride in diethyl ether;dichloromethane at 20;

Steps:

6C EXAMPLE 6C; 4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine

A solution of Example 6B (0.5 g, 1.8 mmol) in dichloromethane (5 ML) at room temperature was treated with 2M HCl in diethyl ether (5 ML), stirred overnight, and concentrated to provide the desired product (0.45 g, 95%). MS (ESI) m/e 178 (M+H)+.

References:

US2003/236247,2003,A1 Location in patent:Page 17