1H-BENZIMIDAZOLE, 6-CHLORO-2-PHENYL- synthesis
- Product Name:1H-BENZIMIDAZOLE, 6-CHLORO-2-PHENYL-
- CAS Number:4926-65-2
- Molecular formula:C13H9ClN2
- Molecular Weight:228.68
Yield:4926-65-2 98%
Reaction Conditions:
with oxygen;cobalt(II) hydroxide in ethanol at 20; for 4 h;
Steps:
General procedure: To a mixture of 1,2-phenylenediamine (1.0 mmol) and aldehyde (1.2 mmol) in ethanol (3 mL) under open oxygen atmosphere, 10 mol % of the catalysts were added. The resulting mixture was stirred at room temperature for appropriate time (refPreviewPlaceHolderTable 2). After completion of the reaction, as monitored by TLC, the reaction mixture was diluted with ethanol (20 mL) and the catalyst was separated by filtration. The organic layer was concentrated under reduced pressure and the crude product was purified by silicagel column chromatography using ethyl acetate-n-hexane (1:9) as eluent to afford pure benzimidazole product. The spectral data are in full agreement with the data reported in literature.refPreviewPlaceHolder [48] , refPreviewPlaceHolder[54] and refPreviewPlaceHolder[55] Some of the compounds' spectral data are given below.
References:
Adharvana Chari, Murugulla;Shobha, Donthabhakthuni;Sasaki, Takehiko [Tetrahedron Letters,2011,vol. 52,# 43,p. 5575 - 5580] Location in patent:experimental part
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