ChemicalBook CAS DataBase List 1H-Indazole-3-acetic acid, Methyl ester

1H-Indazole-3-acetic acid, Methyl ester synthesis

5synthesis methods

Product Name:1H-Indazole-3-acetic acid, Methyl ester
CAS Number:131666-74-5
Molecular formula:C10H10N2O2
Molecular Weight:190.2

67-56-1 Synthesis

67-56-1
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$9.00/25ml

26663-42-3 Synthesis

26663-42-3
91 suppliers
$73.00/100mg

131666-74-5
46 suppliers
$63.00/100mg

Yield:131666-74-5 93%

Reaction Conditions:

with sulfuric acid at 68; for 16 h;

Steps:

Synthesis of (1H-Indazol-3-yl)-acetic acid methyl ester (35-2):

To a stirred solution of 2-(1H-indazol-3-yl)acetic acid (35-1) (4.86 g, 27.5 mmol) in Methanol (250 mL ) was added sulfuric acid (0.543 g, 5.53 mmol) and the reaction was refluxed at 68°C for 16 h. Reaction progress was monitored by TLC. The MeOH was evaporated to dryness and the residual gum was basified with saturated sodium bicarbonate solution and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulphate and evaporated in vacuo to yield methyl 2-(1H-indazol-3-yl)acetate (35-2) (4.90 g, 25.7 mmol, 93 %) as a light brown solid.

References:

WO2017/197046,2017,A1 Location in patent:Page/Page column 328

26663-42-3 Synthesis

26663-42-3
91 suppliers
$73.00/100mg

131666-74-5
46 suppliers
$63.00/100mg

References

26663-42-3 Synthesis

26663-42-3
91 suppliers
$73.00/100mg