ChemicalBook CAS DataBase List Methyl 4-hydroxyquinazoline-7-carboxylate

Methyl 4-hydroxyquinazoline-7-carboxylate synthesis

4synthesis methods

Product Name:Methyl 4-hydroxyquinazoline-7-carboxylate
CAS Number:313535-84-1
Molecular formula:C10H8N2O3
Molecular Weight:204.18

67-56-1 Synthesis

67-56-1
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$9.00/25ml

3,4-DIHYDRO-4-OXOQUINAZOLINE-7-CARBOXYLIC ACID

202197-73-7
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$59.00/100mg

Methyl 4-hydroxyquinazoline-7-carboxylate

313535-84-1
63 suppliers
$45.00/50mg

Yield:313535-84-1 86%

Reaction Conditions:

with sulfuric acid at 60; for 11 h;

Steps:

31.3 Step 3: Methyl 4-oxo-3,4-dihydroquinazoline-7-carboxylate

To a solution of 4-oxo-3,4-dihydroquinazoline-7-carboxylic acid (3.30g, 14.8 mmol) in 60 mL methanol was added 6.6 mL of sulfuric acid. The resulting mixture was stirred at 60 °C for 11 hours. After cooled to room temperature, the solvent was removed in vacuo and the residue was diluted with water. Aqueous sodium hydroxide (6 mol/L) was added to adjust the pH value to 8 and the precipitated solid was collected by filtration. The filter cake was washed with water and dried in oven to give 3.00 g (86%) of the product as a light yellow solid. MS (ESIpos): m/z = 205 (M+H)⁺. LC-MS [Method 2]: R_t = 0.67 min.

References:

WO2019/170543,2019,A1 Location in patent:Page/Page column 71-72

5372-81-6 Synthesis