![](/CAS/GIF/4498-68-4.gif)
1H-INDAZOLE-3-CARBOXYLIC ACID ETHYL ESTER synthesis
- Product Name:1H-INDAZOLE-3-CARBOXYLIC ACID ETHYL ESTER
- CAS Number:4498-68-4
- Molecular formula:C10H10N2O2
- Molecular Weight:190.2
![p-Cymene](/CAS/GIF/99-87-6.gif)
99-87-6
234 suppliers
$16.00/25mL
![4,5,6,7-TETRAHYDRO-1H-INDAZOLE-3-CARBOXYLIC ACID ETHYL ESTER](/CAS/GIF/4492-02-8.gif)
4492-02-8
83 suppliers
$19.00/250mg
![1H-INDAZOLE-3-CARBOXYLIC ACID ETHYL ESTER](/CAS/GIF/4498-68-4.gif)
4498-68-4
114 suppliers
$16.00/100mg
Yield:-
Reaction Conditions:
palladium
Steps:
5 Indazole-3-Carboxylic Acid
Preparation 5 Indazole-3-Carboxylic Acid A mixture of 4,5,6,7-tetrahydroindazole-3-carboxylic acid ethyl ester (21.0 g, 108 mmol), 5% palladium on carbon (7.0 g solid, 3.29 mmol of Pd), and 210 mL of cymene was heated to reflux for 38 hours. At this point complete conversion to the indazole-3-carboxylic acid ethyl ester was shown by TLC (silica gel, 3:1 ethyl acetate-heptane). The reaction was cooled to 120° C. and the 5% palladium on carbon was removed by filtration.
References:
Eli Lilly and Company US6069152, 2000, A
![Ethyl diazoacetate](/CAS/GIF/623-73-4.gif)
623-73-4
144 suppliers
$26.69/5g
![2-(TRIMETHYLSILYL)PHENYL TRIFLUOROMETHANESULFONATE](/CAS/GIF/88284-48-4.gif)
88284-48-4
165 suppliers
$9.00/250mg
![1H-INDAZOLE-3-CARBOXYLIC ACID ETHYL ESTER](/CAS/GIF/4498-68-4.gif)
4498-68-4
114 suppliers
$16.00/100mg
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1000210-73-0
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![1H-INDAZOLE-3-CARBOXYLIC ACID ETHYL ESTER](/CAS/GIF/4498-68-4.gif)
4498-68-4
114 suppliers
$16.00/100mg
![Ethyl diazoacetate](/CAS/GIF/623-73-4.gif)
623-73-4
144 suppliers
$26.69/5g
![2-(TRIMETHYLSILYL)PHENYL TRIFLUOROMETHANESULFONATE](/CAS/GIF/88284-48-4.gif)
88284-48-4
165 suppliers
$9.00/250mg
![1H-Indazole-3-carboxylic acid, 1-phenyl-, ethyl ester](/CAS/20180808/GIF/7716-35-0.gif)
7716-35-0
3 suppliers
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![1H-INDAZOLE-3-CARBOXYLIC ACID ETHYL ESTER](/CAS/GIF/4498-68-4.gif)
4498-68-4
114 suppliers
$16.00/100mg
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64-17-5
706 suppliers
$10.00/50g
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4498-67-3
463 suppliers
$6.00/5g
![1H-INDAZOLE-3-CARBOXYLIC ACID ETHYL ESTER](/CAS/GIF/4498-68-4.gif)
4498-68-4
114 suppliers
$16.00/100mg