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ChemicalBook CAS DataBase List Indazole

Indazole synthesis

9synthesis methods
-

Yield:271-44-3 73%

Reaction Conditions:

with hydrazine hydrate;sodium t-butanolate;[Pd(cinnamyl)Cl]2;C27H38NP in toluene at 65; for 1.5 h;

Steps:

8
[0251] In Example 8, 1-H-indazoles were prepared directly from 2-chlorobenzaldehydes and hydrazine. The protocol above allows for the generation of substituted NH-indazoles with moderate to good yields in short reaction times (1 - 1.5 h) and under relatively mild conditions (65 - 90 °C

References:

DALHOUSIE UNIVERSITY;LUNDGREN, Rylan, J.;STRADIOTTO, Mark WO2012/68335, 2012, A2 Location in patent:Page/Page column 60-61

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