1H-Indene-1,3(2H)-dione, 2-chloro- synthesis

5synthesis methods

Product Name:1H-Indene-1,3(2H)-dione, 2-chloro-
CAS Number:876-84-6
Molecular formula:C9H5ClO2
Molecular Weight:180.59

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Yield:876-84-6 86%

Reaction Conditions:

with N-chloro-N-fluoro-benzenesulfonamide;potassium carbonate in acetonitrile at 20;Reagent/catalyst;

Steps:

4

To-neck flask was added 25mL 5mL of acetonitrile, 0.07g of potassium carbonate, 0.09g of the chlorinating agent, 0.050g trans Shall substrate, stirred at room temperature overnight, TLC monitored the reaction. After completion of the reaction was monitored by TLC, column chromatography. Chromatography type Adsorption column chromatography, column temperature is room temperature (20-35 ° C), the adsorbent is silica gel, gradient elution, column diameter high as 15: 1, Dry-packed, dry sample, elution rate of 1-2 drops per second. Eluent PE: EA = 10: 1 (by volume), separated The resulting spin eluent After evaporation of the solvent, chlorinated products (0.055g, yield about 86%).

References:

CN104610100,2016,B Location in patent:Paragraph 0041-0044

876-82-4 Synthesis

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References

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References

1H-Indene-1,3(2H)-dione, 2-bromo-2-chloro-

109098-95-5
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References

2-Propenoic acid, 2,3-dichloro-3-phenyl-, (E)- (9CI)

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References