ChemicalBook CAS DataBase List 1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro-

1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro- synthesis

7synthesis methods

Product Name:1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro-
CAS Number:633328-98-0
Molecular formula:C5H3ClN4
Molecular Weight:154.56

Ethanone, 1-(5-chloro-1H-pyrazolo[4,3-d]pyriMidin-1-yl)-

633328-97-9
18 suppliers
$462.00/1g

633328-98-0
76 suppliers
$69.00/100mg

Yield:633328-98-0 93%

Reaction Conditions:

with hydrogenchloride in tetrahydrofuran;water at 50; for 0.5 h;Reflux;

Steps:

c) 5-Chloro-1H-pyrazolo[4,3-d]pyrimidine
To a stirred solution of 1-(5-chloro-pyrazolo[4,3-d]pyrimidin-1-yl)-ethanone (1.5 g, 7.65 mmol) in THF (15 mL) was added 8% aqueous HC1 (14.46 mL) at 50°C and reaction mixture was refluxed for 30 mm. After completion of the reaction, it was cooled to 25°C and was extractedwith EtOAc (2xSOmL). The combined organic layers were dried over Na2504, filtered and concentrated under reduced pressure to yield the title compound as an off-white solid (1.1 g, 93%). MS (ESI): mlz = 153.0 [M-H].

References:

F. HOFFMANN-LA ROCHE AG;HOFFMANN-LA ROCHE INC.;BUETTELMANN, Bernd;KOCER, Buelent;KUHN, Bernd;PRUNOTTO, Marco;RICHTER, Hans;RITTER, Martin WO2017/137334, 2017, A1 Location in patent:Page/Page column 123; 124

FullText

20090-69-1 Synthesis

5-Pyrimidinamine, 2-chloro-4-methyl- (9CI)

20090-69-1
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633328-98-0
76 suppliers
$69.00/100mg

References

Acetamide, N-(2-chloro-4-methyl-5-pyrimidinyl)-

633328-96-8
14 suppliers
$220.00/50mg

633328-98-0
76 suppliers
$69.00/100mg

References

626-48-2 Synthesis

626-48-2
375 suppliers
$10.00/25 g

633328-98-0
76 suppliers
$69.00/100mg

References

16632-21-6
244 suppliers
$5.00/1g

633328-98-0
76 suppliers
$69.00/100mg

References