1H-pyrido[2,3-d][1,3]oxazine-2,4-dione synthesis

6synthesis methods

Product Name:1H-pyrido[2,3-d][1,3]oxazine-2,4-dione
CAS Number:21038-63-1
Molecular formula:C7H4N2O3
Molecular Weight:164.12

699-98-9 Synthesis

699-98-9
263 suppliers
$10.00/5g

21038-63-1
31 suppliers
$62.00/100mg

Yield: 58%

Reaction Conditions:

with trimethylsilylazide

Steps:

1.A 2H-pyrido[2,3-d][1,3]oxazine-2,4(1H)-dione
2H-pyrido[2,3-d][1,3]oxazine-2,4(1H)-dione The title compound was prepared from 2,3-pyridinecarboxylic anhydride (11.4 g, 76 mmol) and trimethylsilyl azide (11.0 ML, 80 mmol) according to the procedure described in Synthesis, 1982, 972-973 as a white solid (7.27 g, 58%).1H NMR (300 MHz, DMSO-d6) δ 7.31 (dd, J=7.72, 4.78 Hz, 1H), 8.31 (dd, J=7.72, 1.84 Hz, 1H), 8.66 (dd, J=4.78, 1.84 Hz, 1H), 12.27 (s, 1H).

References:

Pratt, John K.;Betebenner, David A.;Donner, Pamela L.;Green, Brian E.;Kempf, Dale J.;McDaniel, Keith F.;Maring, Clarence J.;Stoll, Vincent S.;Zhang, Rong US2004/167123, 2004, A1 Location in patent:Page/Page column 70

5860-70-8 Synthesis