ChemicalBook CAS DataBase List 1H-PYRROLO[2,3-B]PYRIDIN-5-OL

1H-PYRROLO[2,3-B]PYRIDIN-5-OL synthesis

15synthesis methods

Product Name:1H-PYRROLO[2,3-B]PYRIDIN-5-OL
CAS Number:98549-88-3
Molecular formula:C7H6N2O
Molecular Weight:134.14

1036007-71-2 Synthesis

1036007-71-2
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98549-88-3
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Yield:98549-88-3 95.5%

Reaction Conditions:

with palladium on activated charcoal;hydrogen in methanol;

Steps:

8 Preparation of 5-hydroxy-7-azaindole

Add 22.4g of 5-benzyloxy-7-azaindole to the hydrogenation bottle, dissolve it with methanol, add 1.1g of palladium carbon, replace the air in the hydrogenation bottle with hydrogen, and then add hydrogen. Stop the reaction after the pressure in the bottle does not change The palladium carbon was removed by filtration, and the organic solvent was swirled to obtain a crude product, which was washed with n-heptane to obtain 12.8 g of a refined product with a yield of 95.5%

References:

CN110922404,2020,A Location in patent:Paragraph 0051-0054