ChemicalBook CAS DataBase List 1H-Pyrrolo[2,3-b]pyridine, 3-broMo-2-Methyl-

1H-Pyrrolo[2,3-b]pyridine, 3-broMo-2-Methyl- synthesis

5synthesis methods

Product Name:1H-Pyrrolo[2,3-b]pyridine, 3-broMo-2-Methyl-
CAS Number:145934-58-3
Molecular formula:C8H7BrN2
Molecular Weight:211.06

23612-48-8 Synthesis

23612-48-8
136 suppliers
$18.00/250mg

1H-Pyrrolo[2,3-b]pyridine, 3-broMo-2-Methyl-

145934-58-3
43 suppliers
$65.00/50mg

Yield:145934-58-3 85%

Reaction Conditions:

with bromine in N,N-dimethyl-formamide at 20; for 4 h;

Steps:

38.1 Step 1: 3 -bromo-2-methyl- 1 H-pyrrolo[2,3 -blpyridine

[00396] To a solution of 2-methyl-1H-pyrrolo[2,3-b]pyridine (500 mg, 3.78 mmol) in DMF (8 mL) was added bromine (0.22 mL, 4.16 mmol). The reaction mixture was stirred at r.t. for 4 h. A saturated aqueous Na25203 solution (100 mL) was added, and the resulting mixture was extracted with EtOAc (100 mL x 2). The combined organic phases were washed with saturated brine (100 mL x 3), dried over Na2504, filtered, and the filtrate was concentrated in vacuo. The residue was purified by silica gel chromatograph (PE/EtOAc (v/v) = 4/1) to give the tilte compound as a yellow solid (679 mg, 85%).1H NMR (400 MHz, DMSO-d6) (ppm): 12.19 (s, 1H), 8.27 (d, J = 4.8 Hz, 1H), 7.82 (d, J = 7.8 Hz, 1H), 7.15 (dd, J 7.8, 4.9 Hz, 1H), 2.56 (s, 3H).

References:

WO2017/97234,2017,A1 Location in patent:Paragraph 00396

3-broMo-2-Methyl-1-(phenylsulfonyl)-1H-pyrrolo[2.3-b]pyridine

744209-37-8
29 suppliers
$294.00/250mg

145934-58-3
43 suppliers
$65.00/50mg

References

271-63-6
571 suppliers
$9.00/5g

145934-58-3
43 suppliers
$65.00/50mg

References

143141-23-5 Synthesis

1H-Pyrrolo[2,3-b]pyridine, 1-(phenylsulfonyl)-

143141-23-5
78 suppliers
$30.00/1g

145934-58-3
43 suppliers
$65.00/50mg

References

2-Methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

189089-83-6
30 suppliers
inquiry

145934-58-3
43 suppliers
$65.00/50mg

References