1H-Pyrrolo[2,3-b]pyridine-3-carboxamide(9CI) synthesis

3synthesis methods

Product Name:1H-Pyrrolo[2,3-b]pyridine-3-carboxamide(9CI)
CAS Number:74420-16-9
Molecular formula:C8H7N3O
Molecular Weight:161.16

1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONITRILE

4414-89-5
89 suppliers
$25.00/250mg

1H-Pyrrolo[2,3-b]pyridine-3-carboxamide(9CI)

74420-16-9
18 suppliers
$279.23/1gm:

Yield:74420-16-9 95%

Reaction Conditions:

Stage #1: 1H-pyrrolo[2,3-b]pyridine-3-carbonitrilewith sulfuric acid at 20; for 1 h;
Stage #2: with sodium hydroxide

Steps:

3.1.3. General Procedure for the Synthesis of 1H-Pyrrolo[2,3-b]pyridine-3-carboxamides (6a,b)

General procedure: A solution of appropriate carbonitriles 5a,b (6.3 mmol) in concentrate sulphuric acid (3.32 mL) was stirred at room temperature for 15-60 min. The solution was slowly poured into ice and basified with concentrated NaOH. The residue was extracted with ethyl acetate (3 × 20 mL), dried (Na₂SO₄) and concentrated under reduced pressure to afford the carboxamides 6a,b.

References:

Carbone, Anna;Parrino, Barbara;Vita, Gloria Di;Attanzio, Alessandro;Span, Virginia;Montalbano, Alessandra;Barraja, Paola;Tesoriere, Luisa;Livrea, Maria Antonia;Diana, Patrizia;Cirrincione, Girolamo [Marine Drugs,2015,vol. 13,# 1,p. 460 - 492]

2,2,2-trichloro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone

163220-69-7
23 suppliers
$107.00/100mg

74420-16-9
18 suppliers
$279.23/1gm:

References

271-63-6
567 suppliers
$9.00/5g

74420-16-9
18 suppliers
$279.23/1gm:

References