1N-BOC 4-(2'-METHYL-4'-NITROPHENOXY) PIPERIDINE synthesis

4synthesis methods

Product Name:1N-BOC 4-(2'-METHYL-4'-NITROPHENOXY) PIPERIDINE
CAS Number:138227-68-6
Molecular formula:C17H24N2O5
Molecular Weight:336.38

455-88-9 Synthesis

455-88-9
300 suppliers
$6.00/10g

109384-19-2 Synthesis

109384-19-2
484 suppliers
$5.00/1g

1N-BOC 4-(2'-METHYL-4'-NITROPHENOXY) PIPERIDINE

138227-68-6
12 suppliers
$1131.00/5g

Yield:138227-68-6 107 g

Reaction Conditions:

Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylatewith sodium hydride in N,N-dimethyl-formamide at 10 - 15; for 0.5 h;
Stage #2: 5-nitro-2-fluorotoluene in N,N-dimethyl-formamide at 20; for 3 h;Further stages.;

References:

Lippa, Blaise;Kauffman, Goss S.;Arcari, Joel;Kwan, Tricia;Chen, Jinshan;Hungerford, William;Bhattacharya, Samit;Zhao, Xumiao;Williams, Courtney;Xiao, Jun;Pustilnik, Leslie;Su, Chunyan;Moyer, James D.;Ma, Ling;Campbell, Mary;Steyn, Stefanus [Bioorganic and Medicinal Chemistry Letters,2007,vol. 17,# 11,p. 3081 - 3086]

99-53-6 Synthesis