ChemicalBook CAS DataBase List 2-Methyl-4-nitrophenol

2-Methyl-4-nitrophenol synthesis

10synthesis methods

Product Name:2-Methyl-4-nitrophenol
CAS Number:99-53-6
Molecular formula:C7H7NO3
Molecular Weight:153.14

2-methyl-4-nitrophenol is prepared by the reaction of 2-methyl-4-nitroaniline with sodium hydroxide and hydrochloric acid.

99-52-5 Synthesis

99-52-5
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$5.00/5 g

99-53-6
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$9.00/5g

Yield:99-53-6 98.5%

Reaction Conditions:

with water;sodium hydroxide for 50 h;Reflux;Reagent/catalyst;

Steps:

2 Example 1
Equipped with a thermometer, a stirrer, a reflux condenser, 2000 ml four-necked flask was added p-nitro-o-toluidine 30.4g (0.2mol) and 900ml of water and 100g of sodium hydroxide was heated to reflux and held for 50 hours after heating was stopped, Add 500ml of water, Filtered and the filtrate was slowly added hydrochloric acid to adjust the pH of the reaction solution to about 3, Filter the Precipitated yellow solid after cooling to room temperature. 1000ml water was used to wash the filtr cake. It was washed three times and drained. It was then dried for 4 hours at 50°C using Vacuum drying oven to give a yellow nitro-o-cresol solid, yield 98.5%.

References:

Chinese Academy of Agricultural Sciences Shanghai Veterinary Institute;Zhang, Lifang;Xue, Feiqun;Zhu, Jiande;Fei, Chenzhong;Wang, Mi;Wang, Xiaoyang;Zheng, Wenli;Zhang, Keyu;Wang, Chunmei CN105693522, 2016, A Location in patent:Paragraph 0015; 0016

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