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ChemicalBook CAS DataBase List 2,1,3-BENZOTHIADIAZOLE-5-CARBONYL CHLORIDE
321309-31-3

2,1,3-BENZOTHIADIAZOLE-5-CARBONYL CHLORIDE synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: thionyl chloride; sodium hydrogencarbonate / 14 h / 0 - 25 °C / Inert atmosphere; Schlenk technique
2: thionyl chloride; triethylamine; sodium hydrogencarbonate / dichloromethane / 6 h / 0 - 80 °C / Inert atmosphere; Schlenk technique
3: sodium hydroxide / water; 1,4-dioxane / 16 h / 25 °C / Inert atmosphere; Schlenk technique
4: thionyl chloride / 3 h / 80 °C / Inert atmosphere; Schlenk technique

References:

G?bel, Dominik;Rusch, Pascal;Duvinage, Daniel;Stauch, Tim;Bigall, Nadja-C.;Nachtsheim, Boris J. [Journal of Organic Chemistry,2021,vol. 86,# 21,p. 14333 - 14355]

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