ChemicalBook CAS DataBase List 2(1H)-Quinoxalinone, 6-broMo-3,4-dihydro-

2(1H)-Quinoxalinone, 6-broMo-3,4-dihydro- synthesis

4synthesis methods

Product Name:2(1H)-Quinoxalinone, 6-broMo-3,4-dihydro-
CAS Number:854584-01-3
Molecular formula:C8H7BrN2O
Molecular Weight:227.06

AcetaMide, N-(2-aMino-4-broMophenyl)-2-chloro-

854583-92-9
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2(1H)-Quinoxalinone, 6-broMo-3,4-dihydro-

854584-01-3
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$65.00/60mg

Yield: 34%

Reaction Conditions:

with sodium carbonate;sodium iodide in acetonitrileReflux;Inert atmosphere;

Steps:

18
A mixture of N-(2-amino-4-bromophenyl)-2-chloroacetamide (4.5 g, 17.0 mmol), sodium iodide (101 mg, 2.0 mmol) and sodium carbonate (3.6 g, 33.8 mmol) in 300 ml acetonitrile was refluxed overnight under an atmosphere of nitrogen. Then the acetonitrile was removed under vacuum. The resulting solid was suspended in 150 ml water acidified to pH 5-6 with 1 N HCl. Extraction with ethyl acetate, washing of the combined organic layers with brine, drying over MgSO₄, removing the solvent under reduced pressure and purification of the crude product by flash chromatography on silica gel (petroleum ether/ethyl acetate, 1.5/1) yielded 6-bromo-3,4-dihydroquinoxalin-2(1H)-one (1.3 g, 5.8 mmol, 34%) as yellow solid.

References:

Universitat des Saarlandes US2011/112067, 2011, A1 Location in patent:Page/Page column 33

875-51-4 Synthesis

875-51-4
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854584-01-3
54 suppliers
$65.00/60mg

References

AcetaMide, N-(4-broMo-2-nitrophenyl)-2-chloro-

854583-85-0
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$251.00/1g

854584-01-3
54 suppliers
$65.00/60mg

References

321-23-3
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$10.00/1g

854584-01-3
54 suppliers
$65.00/60mg

References