ChemicalBook CAS DataBase List 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL

2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL synthesis

8synthesis methods

Product Name:2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL
CAS Number:5197-62-6
Molecular formula:C6H13ClO3
Molecular Weight:168.62

2-(2-(2-chloroethoxy)ethoxy)ethanol can be used as an intermediate for drugs such as PranedipineTartrate and LJP-920 for laboratory research and development and chemical production. It was prepared from 2-(2-Chloroethoxy)ethanol, Ethylene oxid with boron trifluoride diethyl etherate by stirring for 2.5 h at 45 - 55℃.

112-27-6 Synthesis

112-27-6
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$6.00/100g

5197-62-6
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$24.00/5g

Yield:5197-62-6 84%

Reaction Conditions:

with thionyl chloride at 70; for 6 h;

Steps:

1
_{3.0g of triethylene glycol was dissolved in 20mL of sulfoxide chloride (SOCl2), heated to 70 ° C and stirred for 6 hours.After the reaction, the product was concentrated to obtain a crude product, which was separated by column chromatography (200-300 mesh silica gel, eluent: n-hexane: ethyl acetate = 1: 1) to obtain pure intermediate 60.}

References:

ShanghaiTech University;Tao Houchao;Zhao Fei CN110894209, 2020, A Location in patent:Paragraph 0085; 0252; 0254; 0263

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