ChemicalBook CAS DataBase List 2,2,2-trifluoro-1-(naphthalen-1-yl)ethanol

2,2,2-trifluoro-1-(naphthalen-1-yl)ethanol synthesis

10synthesis methods

Product Name:2,2,2-trifluoro-1-(naphthalen-1-yl)ethanol
CAS Number:17556-44-4
Molecular formula:C12H9F3O
Molecular Weight:226.19

66-77-3
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$7.00/10g

81290-20-2 Synthesis

81290-20-2
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$13.00/1g

2,2,2-trifluoro-1-(naphthalen-1-yl)ethanol

17556-44-4
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Yield:17556-44-4 97%

Reaction Conditions:

Stage #1: 1-naphthaldehyde;(trifluoromethyl)trimethylsilanewith tetrabutyl ammonium fluoride in tetrahydrofuran at -20 - 20; for 6 h;
Stage #2: with water in tetrahydrofuran at 0 - 20; for 16 h;

References:

Czerwiński, Pawe?;Molga, Edyta;Cavallo, Luigi;Poater, Albert;Michalak, Micha? [Chemistry - A European Journal,2016,vol. 22,# 24,p. 8089 - 8094] Location in patent:supporting information