ChemicalBook CAS DataBase List 2,2,2-Trifluoroethyl trifluoromethanesulfonate

2,2,2-Trifluoroethyl trifluoromethanesulfonate synthesis

11synthesis methods

Product Name:2,2,2-Trifluoroethyl trifluoromethanesulfonate
CAS Number:6226-25-1
Molecular formula:C3H2F6O3S
Molecular Weight:232.1

In a 100-ml flask equipped with a stirrer, a thermometer, a nitrogen introducing pipe, and a condenser, 50 ml (0.297 mol) of trifluoromethane sulfonic anhydride and 25 ml (0.342 moles) of 2,2,2-trifluoroethanol were placed at room temperature and stirred for 30 minutes in a nitrogen atmosphere, followed by reflux for 3 hours. After distillation, 50.3 g of 2,2,2-trifluoroethyl trifluoromethanesulfonate was obtained in a yield of 73%.

2,2,2-Trifluoroethyl trifluoromethanesulfonate

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15458-53-4 Synthesis

15458-53-4
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6226-25-1
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Yield:6226-25-1 95%

Reaction Conditions:

with potassium carbonate in xylene at 25; for 1.2 h;Product distribution / selectivity;Inert atmosphere;

Steps:

5

The following are introduced under nitrogen into a 150 ml glass reactor: K₂CO₃ 7 g (50.14 mmol) TFE 3.2 g (32 mmol) solvent 7 g The resulting heterogeneous medium is brought with stirring to a temperature T mentioned in the following table (I) and then TFSBr (7 g, 32 mmol), diluted with TFE (3.2 g, 32 mmol) or with a solvent (7 g), is added over a time t also mentioned in table (I).After the addition, the reaction medium is maintained at the temperature T' for a time t' mentioned in table (I) and then the reactants and the products obtained are quantitatively determined by ¹⁹F NMR.The results obtained are recorded in table (I).

References:

US2011/190542,2011,A1 Location in patent:Page/Page column 4

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358-23-6 Synthesis