2-(2,5-dimethoxyphenyl)propan-2-ol synthesis

8synthesis methods

Product Name:2-(2,5-dimethoxyphenyl)propan-2-ol
CAS Number:72667-90-4
Molecular formula:C11H16O3
Molecular Weight:196.2429

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676-58-4 Synthesis

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Yield:72667-90-4 95%

Reaction Conditions:

with choline chloride;urea in tetrahydrofuran;water at 25; for 0.00555556 h;

Steps:

4.2. Synthesis of alcohols 3 by addition of organolithium or Grignard reagents to esters 1 in water or DES. General procedure

General procedure: In a 10mL Schlenk-like flask, aryl or alkyl ester 1 (0.5 mmol)was added to 1.0 mL of water or 1.0 g of DES, at room temperature in air,and the resulting mixture was vigorously stirred. A solution of the corresponding organolithium or Grignard reagent (2.5 equiv),handled under argon using conventional Schlenk techniques, was rapidly spread over the mixture under air and with vigorous stirring at room temperature to generate an emulsion. After 20 s, the reaction mixture was diluted with 2 mL of water, and then extracted with CPME (3.0 mL 3). The volatiles were removed under reduced pressure, and the residue was purified by column chromatography on silica gel (hexane/EtOAc, 8/2) to provide the desired product.

References:

Quivelli, Andrea F.;D'Addato, Giovanna;Vitale, Paola;García-álvarez, Joaquín;Perna, Filippo M.;Capriati, Vito [Tetrahedron,2021,vol. 81]