2-(2-BROMO-6-CHLOROPHENYL)-2-METHYLPROPANENITRILE synthesis
1synthesis methods
- Product Name:2-(2-BROMO-6-CHLOROPHENYL)-2-METHYLPROPANENITRILE
- CAS Number:1314771-96-4
- Molecular formula:C10H9BrClN
- Molecular Weight:258.54
Yield:1314771-96-4 90%
Reaction Conditions:
Stage #1: 2-(2-bromo-6-chlorophenyl)acetonitrilewith potassium tert-butylate in tetrahydrofuran;1-methyl-pyrrolidin-2-one at 0; for 0.166667 h;Inert atmosphere;
Stage #2: methyl iodide in tetrahydrofuran;1-methyl-pyrrolidin-2-one at 0 - 10; for 1.16667 h;Inert atmosphere;
References:
Hsieh, Jen-Chieh;Cheng, An-Yi;Fu, Jun-Hao;Kang, Ting-Wei [Organic and Biomolecular Chemistry,2012,vol. 10,# 31,p. 6404 - 6409] Location in patent:supporting information; experimental part