2-(2-BroMophenyl)propanoic acid synthesis

9synthesis methods

Product Name:2-(2-BroMophenyl)propanoic acid
CAS Number:153184-13-5
Molecular formula:C9H9BrO2
Molecular Weight:229.07

Benzeneacetic acid, 2-bromo-a-methyl-, methyl ester

115615-34-4
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153184-13-5
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$135.00/0.5g

Yield:153184-13-5 95%

Reaction Conditions:

with water;sodium hydroxide in tetrahydrofuran;methanol; for 2 h;

Steps:

16 2-(2-bromophenyl)propionic acid

The compound of Reference Example 15 (3.0 g) of tetrahydrofuran (12 mL) and methanol (12 mL)2 mol / L aqueous solution of sodium hydroxide was addedAnd the mixture was stirred for 2 hours.The reaction solution was concentrated under reduced pressure, and the aqueous layer was washed with diethyl ether.A 5% potassium hydrogen sulfate aqueous solution was added to the aqueous layer,And extracted with ethyl acetate.The organic layer was washed with saturated brine,After drying with anhydrous sodium sulfate, filtration and evaporation of the solvent under reduced pressure,The target compound was obtained (2.7 g, 95%).

References:

JP2015/83543,2015,A Location in patent:Paragraph 0193-0195

18698-97-0 Synthesis