2,2-DIFLUOROETHYL P-TOLUENESULFONATE synthesis
- Product Name:2,2-DIFLUOROETHYL P-TOLUENESULFONATE
- CAS Number:135206-84-7
- Molecular formula:C9H10F2O3S
- Molecular Weight:236.24
359-13-7
331 suppliers
$10.00/1g
98-59-9
586 suppliers
$9.00/5g
135206-84-7
68 suppliers
$10.00/100mg
Yield: 100%
Reaction Conditions:
with triethylamine in dichloromethane at 0; for 0.5 h;
Steps:
1 Step 1: 2,2-difluoroethyl 4-methylbenzenesulfonate (A1)
To a solution of compound 2,2-difluoroethanol (8.2 g, 100 mmol) in DCM (200 mL) at 0 oC was added Et3N (15.1 g, 150 mmol) and TsCl (19.0 g, 100 mmol). The resulting mixture was stirred at 0 oC for 0.5 h, then poured into water and extracted with DCM (200 mL x 3). The combined organic layer was dried over MgSO4, filtered and concentrated in vacuo to give the title compound (23.6 g, 100%) as colorless oil without further purification.
References:
MERCK SHARP & DOHME CORP.;KUDUK, Scott, D.;LIVERTON, Nigel;LUO, Yunfu WO2016/89721, 2016, A1 Location in patent:Page/Page column 33
359-13-7
331 suppliers
$10.00/1g
104-15-4
722 suppliers
$133.00/500g
135206-84-7
68 suppliers
$10.00/100mg