![](/CAS/GIF/166108-71-0.gif)
Fmoc-8-amino-3,6-dioxaoctanoic acid synthesis
- Product Name:Fmoc-8-amino-3,6-dioxaoctanoic acid
- CAS Number:166108-71-0
- Molecular formula:C21H23NO6
- Molecular Weight:385.41
![9-Fluorenylmethyl chloroformate](/CAS/GIF/28920-43-6.gif)
28920-43-6
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$5.00/5g
![2-(2-(2-Aminoethoxy)ethoxy)acetic acid](/CAS/GIF/134978-97-5.gif)
134978-97-5
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$17.00/250mg
![Fmoc-8-amino-3,6-dioxaoctanoic acid](/CAS/GIF/166108-71-0.gif)
166108-71-0
385 suppliers
$8.00/100mg
Yield:166108-71-0 203 g
Reaction Conditions:
with hydrogenchloride in ethanol;water; pH=9;
Steps:
3
In a 3000L three-necked flask equipped with mechanical stirring, condenser and constant pressure dropping funnel,330 g of crude product was dissolved in 1000 ml of ethanol, and 400 g of 30% NaOH solution was added dropwise.After the addition is completed, the mixture is heated to reflux, and the TLC is monitored. The etherification intermediate disappears completely and the temperature is lowered.The pH was adjusted to 9 with hydrochloric acid, and 259 g of Fmoc-Cl was added dropwise to dissolve in 1000 ml of ethanol solution.If the pH has dropped, add sodium bicarbonate and keep it at around 8.TLC was monitored until the free amino intermediate disappeared. Adjust the pH to 1-2 with hydrochloric acid,Distill the ethanol, add 1000 ml of water, and extract three times with ethyl acetate 500*3.Wash twice with saturated brine and concentrate ethyl acetate to give 288 g of crude material.Recrystallization from 1000 ml of ethyl acetate gave 203 g of product[2-[1-(Fmoc-Amino)ethoxy]ethoxy]acetic acid, yield 52.68%.
References:
CN110078644,2019,A Location in patent:Paragraph 0077; 0080; 0082
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82911-69-1
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![2-(2-(2-Aminoethoxy)ethoxy)acetic acid](/CAS/GIF/134978-97-5.gif)
134978-97-5
222 suppliers
$17.00/250mg
![Fmoc-8-amino-3,6-dioxaoctanoic acid](/CAS/GIF/166108-71-0.gif)
166108-71-0
385 suppliers
$8.00/100mg
![2-(2-(2-(DIBENZYLAMINO)ETHOXY)ETHOXY) ACETIC ACID](/CAS/20180529/GIF/166108-70-9.gif)
166108-70-9
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![Fmoc-8-amino-3,6-dioxaoctanoic acid](/CAS/GIF/166108-71-0.gif)
166108-71-0
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![2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL](/CAS/GIF/5197-62-6.gif)
5197-62-6
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$24.00/5g
![Fmoc-8-amino-3,6-dioxaoctanoic acid](/CAS/GIF/166108-71-0.gif)
166108-71-0
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$8.00/100mg
![[2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL]-CARBAMIC ACID 9H-FLUOREN-9-YLMETHYL ESTER](/CAS/GIF/560088-66-6.gif)
560088-66-6
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![Fmoc-8-amino-3,6-dioxaoctanoic acid](/CAS/GIF/166108-71-0.gif)
166108-71-0
385 suppliers
$8.00/100mg