2-(2-METHOXYETHOXY)BENZOIC ACID synthesis

4synthesis methods

Product Name:2-(2-METHOXYETHOXY)BENZOIC ACID
CAS Number:98684-32-3
Molecular formula:C10H12O4
Molecular Weight:196.2

143767-40-2
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98684-32-3
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Yield:98684-32-3 93%

Reaction Conditions:

with sodium hydroxide;water at 20 - 25; for 4 h;

Steps:

129 PREPARATION 129; 2-(2-Methoxyethoxy)benzoic Acid

[00391] A mixture of the title compound of Preparation 128 (4.8 g, 22.8 mmol) and 2M aqueous sodium hydroxide solution (25 ml, 50 mmol) was stirred at room temperature for 4 hours, then washed with ether. The resulting aqueous solution was acidified to pH 3 using 1M hydrochloric acid and extracted with dichloromethane (3×50 ml). The combined extracts were dried (MgSO₄) and evaporated under reduced pressure to give the title compound (4.16 g, 93%) as an oil. δ (CDCl₃): 3.50 (3H, s), 3.86 (2H, t), 4.41 (2H, t), 7.08 (1H, d), 7.19 (1H, m), 7.58 (1H, m), 8.22 (1H, d).

References:

US6723719,2004,B1 Location in patent:Page column 73

6482-24-2 Synthesis