2-(3,4,5-TRIMETHOXYPHENYL)-1H-BENZIMIDAZOLE synthesis
- Product Name:2-(3,4,5-TRIMETHOXYPHENYL)-1H-BENZIMIDAZOLE
- CAS Number:175714-45-1
- Molecular formula:C16H16N2O3
- Molecular Weight:284.31
Yield:175714-45-1 92%
Reaction Conditions:
in water; for 1 h;Microwave irradiation;Heating;Green chemistry;
Steps:
4.2. General Methods for Preparation of 2-Substituted Benzimidazoles
General procedure: In a typical procedure, a mixture ofo-phenylenediamine (1 equiv.) and acylbenzotriazole (1 equiv.) was subjected to microwave irradiation (20 W, 50 °C) in water (3 mL) for 1 h. After completion of the reaction, aqueous 4N HCl was added and the precipitates were filtered, followed by washing with water. The isolated products were recrystallized in ethanol to get the desired benzimidazoles in pure form. Benzotriazoles could be recovered from the aqueous layer by pH-controlled acidification.
References:
Ibrahim, Tarek S.;Seliem, Israa A.;Panda, Siva S.;Al-Mahmoudy, Amany M.M.;Abdel-Samii, Zakaria K.M.;Alhakamy, Nabil A.;Asfour, Hani Z.;Elagawany, Mohamed [Molecules,2020,vol. 25,# 11,art. no. 2501]
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