2,3,5-Trimethylpyridine-1-Oxide synthesis
- Product Name:2,3,5-Trimethylpyridine-1-Oxide
- CAS Number:74409-42-0
- Molecular formula:C8H11NO
- Molecular Weight:137.18
695-98-7
307 suppliers
$6.00/5g
74409-42-0
104 suppliers
$80.00/250mg
Yield: 91%
Reaction Conditions:
with dihydrogen peroxide;methyltrioxorhenium(VII) in dichloromethane;water at 20; for 3 h;
Steps:
1
Example 1: Oxidation of the pyridines To a solution of 2,3, 5-colidine (1) (2 g, 0. 016 mol) in dichloromethane (10 ml) was added hydrogen peroxide 30% (5 eq. ) and methyltrioxorhenium (MTO) (1.5% mol). After 3 hours in stirring at room temperature, it was added a aqueous solution of NaHS03 (10 ml). The two phases were separated and the aqueous phase was extracted with dichloromethane (3x50 ml). The organic phases were dried with anhydrous sodium sulfate and the solvent was evaporated, yielding a solid (= 91%).
References:
HERBEX, PRODUTOS QUÍMICOS, SA;SARAGGA, José, Manuel WO2003/97606, 2003, A1 Location in patent:Page/Page column 11
695-98-7
307 suppliers
$6.00/5g
75-09-2
1201 suppliers
$10.00/25 mL
7722-84-1
5 suppliers
$23.30/*2x50ml
74409-42-0
104 suppliers
$80.00/250mg