ChemicalBook CAS DataBase List 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone synthesis

9synthesis methods

Product Name:6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone
CAS Number:179688-29-0
Molecular formula:C14H18N2O5
Molecular Weight:294.3

3473-63-0 Synthesis

3473-63-0
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$5.00/25g

Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate

179688-27-8
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$31.00/250mg

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone

179688-29-0
456 suppliers
$6.00/1g

Yield:179688-29-0 98%

Reaction Conditions:

Stage #1: formamidine acetic acid;ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate in butan-1-ol at 80; for 5 h;Inert atmosphere;
Stage #2: in Isopropyl acetate; for 1 h;Reflux;

Steps:

5 E. Synthesis of Compound (vi) the

Compound (v) (171.1g), formamidine acetate (79.8 g) was dissolved in n-butanol (1027mL), and nitrogen at elevatedTemperature to 80 ° C for 5 hours, the reaction was complete by HPLC. Spin dry n-butanol, was added 1711g of isopropyl acetate heated to reflux for 1Hours, cooled to _5 ° C for 4 hours. Filtered, 50 ° C and dried under blast (vi) (164.0g), yield 98%, purity>95%. NMR data identified compound (vi) as follows

References:

CN103709110,2016,B Location in patent:Paragraph 0067; 0068