ChemicalBook CAS DataBase List 2-(3-BROMOPHENYL)BENZO[D]THIAZOLE

2-(3-BROMOPHENYL)BENZO[D]THIAZOLE synthesis

13synthesis methods

Product Name:2-(3-BROMOPHENYL)BENZO[D]THIAZOLE
CAS Number:19654-14-9
Molecular formula:C13H8BrNS
Molecular Weight:290.18

615-43-0
413 suppliers
$5.00/5g

932-77-4 Synthesis

932-77-4
135 suppliers
$9.00/1g

19654-14-9
62 suppliers
$16.00/1g

Yield:19654-14-9 96%

Reaction Conditions:

with copper(II) acetate monohydrate;sodium carbonate;sulfur in dimethyl sulfoxide at 130; for 24 h;Schlenk technique;Inert atmosphere;

Steps:

General procedure for the synthesis of benzimidazoles

General procedure: 2-Iodoaniline 1a (0.5 mmol), benzyl chloride 2a (1 mmol, 126 mg), sulfur powder (2 mmol, 64 mg), Cu(OAc)₂·H₂O (20 mg) and Na₂CO₃ (1 mmol, 106 mg) in DMSO (3 mL) were put into a Schlenk tube. The reaction mixture was stirred at 130 °C for 24 h and cooled to room temperature, filtered and extracted with ethyl acetate, washed with brine, dried over Na₂SO₄, filtered and concentrated. The residue was purified by chromatography on silica gel (300-400 mesh) to afford desired product 3aa as a light yellow solid; yield : 102 mg (97%);

References:

Yang, Zhao;Hu, Renhe;Li, Xiaotong;Wang, Xin;Gu, Ren;Han, Shiqing [Tetrahedron Letters,2017,vol. 58,# 24,p. 2366 - 2369] Location in patent:supporting information

95-16-9 Synthesis