![](/CAS/GIF/4519-40-8.gif)
2,3-Difluoroaniline synthesis
- Product Name:2,3-Difluoroaniline
- CAS Number:4519-40-8
- Molecular formula:C6H5F2N
- Molecular Weight:129.11
![1,2-DIBROMO-4,5-DIFLUORO-3-NITROBENZENE](/CAS/GIF/1481-57-8.gif)
1481-57-8
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$128.00/1g
![2,3-Difluoroaniline](/CAS/GIF/4519-40-8.gif)
4519-40-8
298 suppliers
$10.00/1g
Yield:4519-40-8 93%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen;triethylamine in methanol at 50; for 2.5 h;Temperature;
Steps:
16 Example 16 (Production of 2,3-difluoroaniline)
First, 0.638 g (2.01 mmol) of 1,2-dibromo-4,5-difluoro-3-nitrobenzene was dissolved in 4 mL of methanol, and then 48.4 mg of 10% Pd/C (50% wet) and 6.2 mg (0.06 mmol) of triethylamine were added. The atmosphere inside the reaction vessel was substituted with hydrogen, and the reaction mixture was reacted at 50°C for 2 hours under slight hydrogen pressurization. Analysis of the resulting reaction product by HPLC revealed 2.2 area% of 2,3-dibromo-5,6-difluoroaniline as a residual intermediate. Reaction was continued under the same conditions for a further 0.5 hours. The catalyst was then removed by filtration. The resulting liquid was subjected to quantitative analysis by HPLC. The yield of 2,3-difluoroaniline was 93%. The intermediate 2,3-dibromo-5,6-difluoroaniline had been eliminated.
References:
EP2940002,2015,A1 Location in patent:Paragraph 0075
![1,2,3-Trifluoro-4-nitrobenzene](/CAS/GIF/771-69-7.gif)
771-69-7
335 suppliers
$5.00/10g
![2,3-Difluoroaniline](/CAS/GIF/4519-40-8.gif)
4519-40-8
298 suppliers
$10.00/1g
![1,2,3-Trichlorobenzene](/CAS/GIF/87-61-6.gif)
87-61-6
214 suppliers
$14.00/25g
![2,3-Difluoroaniline](/CAS/GIF/4519-40-8.gif)
4519-40-8
298 suppliers
$10.00/1g
![2,6-Difluoroaniline](/CAS/GIF/5509-65-9.gif)
5509-65-9
469 suppliers
$10.00/10g
![1,2-Difluorobenzene](/CAS/GIF/367-11-3.gif)
367-11-3
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$10.00/1g
![2,3-Difluoroaniline](/CAS/GIF/4519-40-8.gif)
4519-40-8
298 suppliers
$10.00/1g
![1,2-Dibromo-4,5-difluorobenzene](/CAS/GIF/64695-78-9.gif)
64695-78-9
224 suppliers
$8.00/5g
![2,3-Difluoroaniline](/CAS/GIF/4519-40-8.gif)
4519-40-8
298 suppliers
$10.00/1g