ChemicalBook CAS DataBase List 2',3'-DIHYDROXYACETOPHENONE

2',3'-DIHYDROXYACETOPHENONE synthesis

9synthesis methods

Product Name:2',3'-DIHYDROXYACETOPHENONE
CAS Number:13494-10-5
Molecular formula:C8H8O3
Molecular Weight:152.15

Also obtained by bioconversion of acetophenone through the living cells of Escherichia coli carrying plasmid pUC6256B expressing todCI-bphA2A3A4 and bphB (39.2%).

38480-94-3 Synthesis

38480-94-3
83 suppliers
$33.00/100mg

13494-10-5
90 suppliers
$43.00/100mg

Yield: 91.5%

Reaction Conditions:

with boron tribromide in dichloromethane at -30; for 2 h;

Steps:

1-(2,3-dihydroxyphenyl)ethan-1-one, 30
BBr3 (600 μL, 6.2 mmol) was added to a DCM solution of 29 (383 mg, 3.1 mmol) at -30 . After stirring for 2 h, the reaction was quenched by dropwise added saturated NaHCO3 agueous solution (20 mL) and extracted with DCM. The organic layer was dried over Na2SO4, filtered and concentrated in vacuo to give 30 as light white solid (302 mg, 91.5%).

References:

Sun, De-Yang;Cheng, Chen;Moschke, Katrin;Huang, Jian;Fang, Wei-Shuo [Molecules,2020,vol. 25,# 1,art. no. 102] Location in patent:supporting information

120-80-9 Synthesis