ChemicalBook CAS DataBase List 2,3-Dimethylaniline

2,3-Dimethylaniline synthesis

5synthesis methods

Product Name:2,3-Dimethylaniline
CAS Number:87-59-2
Molecular formula:C8H11N
Molecular Weight:121.18

83-41-0
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$13.00/25g

87-59-2
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$13.00/1g

Yield:87-59-2 95%

Reaction Conditions:

Stage #1:2,3-dimethylnitrobenzene in water at 20; for 0.05 h;Green chemistry;
Stage #2: with glycerol in water at 20; for 1.5 h;Green chemistry;

Steps:

A typical procedure for reduction of nitrobenzene with glycerol/Fe₃O₄(at)APTMS(at)ZrCp₂ system
General procedure: In a round-bottom flask (10 mL) equipped with a magneticstirrer, a mixture of nitrobenzene (1 mmol, 0.123 g) and H2O(2 mL) was prepared. Fe₃O₄(at)APTMS(at)ZrCp₂ (7 mg)was then added and the resulting mixture was stirred for 3 min. Next, glycerol (2 mmol) was added and the reaction mixture was stirred for 40 min at room temperature. TLC monitored the progress of the reaction (eluent, n-hexane/EtOAc: 5/2). After completion of the reaction, the catalyst mixture was extracted with EtOAc (2 × 5 mL). Drying organiclayer over anhydrous Na2SO4followed by evaporation of the solvent affords pure liquid aniline in 96% yield (0.089 g,Table 3, entry 1).

References:

Zeynizadeh, Behzad;Sepehraddin, Farhad [Journal of the Iranian Chemical Society,2017,vol. 14,# 12,p. 2649 - 2657]

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