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ChemicalBook CAS DataBase List 3,5-Dimethylaniline
108-69-0

3,5-Dimethylaniline synthesis

12synthesis methods
-

Yield:108-69-0 96%

Reaction Conditions:

with sodium tetrahydroborate in water at 60; for 0.0166667 h;

Steps:

2.6. A typical procedure for reduction of nitrobenzene to aniline withNaBH4/MMTFe3O4Cu MNPs system

General procedure: In a round-bottom flask (10 mL) containing H2O (2 mL),nitrobenzene (0.123 g, 1 mmol) and MMTFe3O4Cu MNPs(20 mg) was added and the resulting mixture was stirred vigorouslyin an oil bath (60 °C) for 3 min. Next, NaBH4 (0.114 g,3 mmol) was added to the prepared suspension and the mixturewas stirred under oil bath conditions (60 °C) for additional 5 min.Completion of the reaction was monitored by TLC (eluent: n-hexane:EtOAc = 5:1). After that, the magnetic nanocatalyst was separatedfrom the reaction mixture using an external magnetic field.The mixture was then extracted with EtOAc (2 x 4 mL) and thecombined extracts were dried over anhydrous Na2SO4. Evaporationof the solvent under reduced pressure affords the pure liquid anilinein 96% yield (0.0894 g, Table 4, entry 1).

References:

Zeynizadeh, Behzad;Rahmani, Soleiman;Tizhoush, Hengameh [Polyhedron,2020,vol. 175,art. no. 114201]

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