2,4,6-TRIHYDROXYTOLUENE synthesis
- Product Name:2,4,6-TRIHYDROXYTOLUENE
- CAS Number:88-03-9
- Molecular formula:C7H8O3
- Molecular Weight:140.14
487-70-7
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$6.00/250mg
88-03-9
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$85.00/1g
Yield: 99%
Reaction Conditions:
with hydrogenchloride;zinc in diethyl ether;ethyl acetate for 0.166667 h;Cooling with ice;Clemmensen Reduction;
Steps:
Synthesis of intermediate 2:
In a 500 mL single-necked flask, intermediate 1 (10 g, 0.065 mol), ethyl acetate (25 mL), diethyl ether (25 mL), zinc powder (12.73 g, 0.194 mol),In an ice bath, concentrated hydrochloric acid (33 mL) was slowly added dropwise with vigorous stirring. After the addition was completed, the reaction was continued for 10 min. The zinc powder was removed by filtration, water was added, ethyl acetate was extracted, washed with water, and brine was evaporated.Further purification was carried out to obtain 9 g of a white solid, yield 99%.
References:
China Pharmaceutical University;Xu Jinyi;Sun Honghao;Qiu Yangyi;Li Wenlong;Qin Shuai;Zhong Lei;Ye Lianbao;Shen Zhibin;Tang Chunping CN108947787, 2018, A Location in patent:Paragraph 0017
108-73-6
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88-03-9
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6099-90-7
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88-03-9
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$85.00/1g
118-96-7
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$22.39/022s-1.2ml
88-03-9
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95124-62-2
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88-03-9
60 suppliers
$85.00/1g