![](/CAS/GIF/7621-86-5.gif)
2-(4-Aminophenyl)-1H-benzimidazol-5-amine synthesis
- Product Name:2-(4-Aminophenyl)-1H-benzimidazol-5-amine
- CAS Number:7621-86-5
- Molecular formula:C13H12N4
- Molecular Weight:224.26
![5-nitro-2-(4-nitrophenyl)-1H-benzimidazole](/CAS/GIF/1772-39-0.gif)
1772-39-0
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![2-(4-Aminophenyl)-1H-benzimidazol-5-amine](/CAS/GIF/7621-86-5.gif)
7621-86-5
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$9.00/1g
Yield:7621-86-5 96%
Reaction Conditions:
with sodium sulfide;phosphoric acid in water at 100; pH=< 1; for 12 h;
Steps:
1 In the compound having a structure represented by the formula (I), R is a structure represented by the formula (1), and 2-(4-nitrophenyl)-5-nitrobenzimidazole is obtained.
At room temperature,To a 100 mL ml single-necked flask was added 2-(4-nitrophenyl)-5-nitrobenzimidazole (2.84 g, 0.01 mol) and 50 mL of water,Adding phosphoric acid,Adjust the pH below 1.Add sodium sulfide solid (3.9 g, 0.05 mol),Warming up to 100 ° C,Continuous reaction for 12 h. After being cooled to room temperature, it was filtered, and the filtrate was neutralized to a pH of 7 by adding a sodium carbonate aqueous solution having a concentration of 25% by weight, and the product was precipitated from the reaction system, filtered, washed with water several times, and dried to obtain 2.15 g of the product 2-(4). -aminobenzene)-5-aminobenzimidazole (yield 96%, purity (HPLC) >99.9%),
References:
CN108558770,2018,A Location in patent:Paragraph 0079; 0080; 0081
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![2-(4-Aminophenyl)-1H-benzimidazol-5-amine](/CAS/GIF/7621-86-5.gif)
7621-86-5
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$9.00/1g
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97-02-9
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![2-(4-Aminophenyl)-1H-benzimidazol-5-amine](/CAS/GIF/7621-86-5.gif)
7621-86-5
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$9.00/1g
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3460-11-5
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![2-(4-Aminophenyl)-1H-benzimidazol-5-amine](/CAS/GIF/7621-86-5.gif)
7621-86-5
170 suppliers
$9.00/1g