2-(4-bromo-2-chlorophenyl)acetic acid synthesis
- Product Name:2-(4-bromo-2-chlorophenyl)acetic acid
- CAS Number:916516-89-7
- Molecular formula:C8H6BrClO2
- Molecular Weight:249.49
67197-54-0
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916516-89-7
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Yield: 93%
Reaction Conditions:
with potassium hydroxide in waterReflux;
Steps:
2-(4-bromo-2-chlorophenyl)acetic acid (S3)
In a flask, water (196 mL) was added to 2 (19.0 g, 82.4 mmol, 1.0 equiv.) and then KOH (23.1 g, 412 mmol, 5.0 eq,) was added. The mixture was allowed to stir at reflux for 12-18 h, cooled, washed with EtOAc to remove impurities, then acidified with 2 N HCl and extracted with EtOAc (150 mL x 3). The combined organics were washed with brine, dried over MgSO4, filtered, and then reduced to yield S3 as tan crystals (19.1 g, 93 %). Characterization data was identical to previous reports.[20]
References:
Koval, Alexander B.;Wuest, William M. [Tetrahedron Letters,2016,vol. 57,# 3,p. 449 - 451]
185315-48-4
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916516-89-7
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$20.00/250mg
89720-77-4
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916516-89-7
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59748-90-2
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$8.00/1g
916516-89-7
73 suppliers
$20.00/250mg