2-(4-BROMO-PHENYL)-BENZO[D]IMIDAZO[2,1-B]THIAZOLE synthesis

8synthesis methods

Product Name:2-(4-BROMO-PHENYL)-BENZO[D]IMIDAZO[2,1-B]THIAZOLE
CAS Number:7025-33-4
Molecular formula:C15H9BrN2S
Molecular Weight:329.21

136-95-8 Synthesis

136-95-8
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99-73-0 Synthesis

99-73-0
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$10.00/1g

2-(4-BROMO-PHENYL)-BENZO[D]IMIDAZO[2,1-B]THIAZOLE

7025-33-4
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$260.00/1g

Yield:7025-33-4 88%

Reaction Conditions:

in chloroform; for 2 h;Reflux;

Steps:

4.1.7 2-(4-Bromophenyl)imidazo[2,1-b][1,3]benzothiazole (5)

2,4′-Dibromoacetophenone (5.0g, 18mmol) was added to a solution of 2-aminobenzothiazole (4) (2.7g, 18mmol) in CHCl₃ (30mL) and the mixture was refluxed for 2h. After cooling, the deposited crystals were collected by filtration, added of ethanol (20mL) and refluxed with 2M HCl (20mL) for 2h. The mixture was treated with saturated NH₄OH solution and the precipitate was collected and crystallized from EtOH to give 5 (yield 88%; mp 169.1-169.5°C from ethanol; reference [27] 161°C, reference [28] 164°C).

References:

Carosati, Emanuele;Ioan, Pierfranco;Barrano, Giovanni Battista;Caccamese, Salvatore;Cosimelli, Barbara;Devlin, Frank J.;Severi, Elda;Spinelli, Domenico;Superchi, Stefano;Budriesi, Roberta [European Journal of Medicinal Chemistry,2015,vol. 92,p. 481 - 489]

136-95-8 Synthesis

136-95-8
396 suppliers
$7.00/25g