ChemicalBook CAS DataBase List 2,4-Dibromo-3-iodopyridine

2,4-Dibromo-3-iodopyridine synthesis

1synthesis methods

Product Name:2,4-Dibromo-3-iodopyridine
CAS Number:1353056-48-0
Molecular formula:C5H2Br2IN
Molecular Weight:362.79

13534-89-9
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1353056-43-5
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1353056-48-0
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Yield:1353056-43-5 27 %Spectr. ，1353056-48-0 19 %Spectr.

Reaction Conditions:

Stage #1: 2,3-dibromopyridinewith 2,2,6,6-tetramethyl-piperidine;n-butyllithium;ZnCl₂-N,N,N’,N’-tetramethylethylenediamine in tetrahydrofuran at 20; for 2 h;Inert atmosphere;
Stage #2: with iodine in tetrahydrofuran;Inert atmosphere;regioselective reaction;

References:

Snegaroff, Katia;Nguyen, Tan Tai;Marquise, Nada;Halauko, Yury S.;Harford, Philip J.;Roisnel, Thierry;Matulis, Vadim E.;Ivashkevich, Oleg A.;Chevallier, Floris;Wheatley, Andrew E. H.;Gros, Philippe C.;Mongin, Florence [Chemistry - A European Journal,2011,vol. 17,# 47,p. 13284 - 13297] Location in patent:experimental part

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